Synlett

Facile and odorless one-pot process for the synthesis of N-substituted thioamides via TsCl-mediated Beckmann rearrangement of ketoximes

LF Liu, N An, HJ Pi, J Ying, W Du, WP Deng

Index: Liu, Li-Feng; An, Na; Pi, Hong-Jun; Ying, Jun; Du, Wenting; Deng, Wei-Ping Synlett, 2011 , # 7 p. 979 - 981

Full Text: HTML

Citation Number: 7

Abstract

Initially, acetophenone oxime (1a) was chosen as the substrate of model reaction and several common solvents such as THF, dioxane and MeCN were tested in the presence of Et 3 N and MsCl, respectively. In view of the commercial availability and chemical stability, TsCl was also used for the optimization of reaction condition. To our delight, as expected, the reaction proceeded smoothly and generated the desired N-substituted thioamide, and the optimal result was ...