Journal of the American Chemical Society

Photocyclization strategy for the synthesis of antitumor agent CC-1065. Synthesis of the B and C unit fragments

VH Rawal, MP Cava

Index: Rawal, Viresh H.; Cava, Michael P. Journal of the American Chemical Society, 1986 , vol. 108, # 8 p. 2110 - 2112

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Citation Number: 21

Abstract

2: PDE-I 3: PDE-I1 resulted in three clever, and conceptually different, syntheses. 2 The dioxygenated and essentially identical B and C units are like the natural products PDE-I (2) and PDE-I1 (3), which were isolated by Umezawa's group and shown to exhibit inhibitory activity against cyclic adenosine-3', 5'-monophosphate phosphodie~ terase.~ Furthermore, both PDE-I and PDE-I1 were found to have remarkably low toxicity, no signs of toxicity ...