Triprolidine radioimmunoassay: disposition in animals and humans

JWA Findlay, RF Butz, GG Coker…

Index: Findlay; Butz; Coker; et al. Journal of Pharmaceutical Sciences, 1984 , vol. 73, # 10 p. 1339 - 1344

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Citation Number: 25

Abstract

Abstract A hapten derivative of triprolidine, bearing an acrylic acid side chain ortho to the pyridine ring nitrogen atom, was synthesized and coupled to bovine serum albumin. Immunization of New Zealand White rabbits with the resulting drug-protein conjugate resulted in the production of antisera capable of binding a radioiodinated tyramine conjugate of the triprolidine hapten derivative at high antiserum dilutions (1: 70,000-1: ...