Tetrahedron letters

An efficient procedure for the preparation of natural products bearing the 2-(2-phenylethyl) chromone skeleton

DA Williams, C Smith, Y Zhang

Index: Williams, Dwight A.; Smith, Cameron; Zhang, Yan Tetrahedron Letters, 2013 , vol. 54, # 32 p. 4292 - 4295

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Citation Number: 2

Abstract

Several 2-(2-phenylethyl) chromones have been shown to possess neuroprotective activity. However, limited synthetic methods have been disclosed to construct the 2-(2-phenylethyl) chromone skeleton. Herein, we report a straightforward 3-step preparation of five naturally occurring 2-(2-phenylethyl) chromones utilizing the Claisen condensation as the key step.