Enantioselective Aza??Henry Reactions Assisted by ZnII and N??Methylephedrine

C Palomo, M Oiarbide, R Halder…

Index: Palomo, Claudio; Oiarbide, Mikel; Halder, Rajkumar; Laso, Antonio; Lopez, Rosa Angewandte Chemie - International Edition, 2006 , vol. 45, # 1 p. 117 - 120

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Citation Number: 97

Abstract

The addition reaction of nitro compounds to azomethine functions, known as the aza-Henry (or nitro-Mannich) reaction,[1] is a highly valuable CÀC bond-forming process. The resulting 1, 2-nitroamine adducts can be transformed into 1, 2-diamines [2] by reduction [3] as well as α-amino acids by a Nef oxidation.[4] Whereas the production of both families of target molecules in nonracemic form bears considerable interest, the use of the aza-Henry ...