Resorcinol congeners of dopamine derived from benzocycloheptene and indan

JG Cannon, JP Pease, RL Hamer, M Ilhan…

Index: Cannon, Joseph G.; Pease, Jonathan P.; Hamer, Richard L.; Ilhan, Mustafa; Bhatnagar, Ranbir K.; Long, John P. Journal of Medicinal Chemistry, 1984 , vol. 27, # 2 p. 186 - 189

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Citation Number: 12

Abstract

Series of N-alkylated derivatives of 2-amino-4, 6-dihydroxyindan 3 and 6-amino-l, 3- dihydroxybenzocycloheptene 2 were prepared for pharmacological testing as congeners of 2-amino-5, 7-dihydroxytetralin, which elicits dopaminergic effects in a variety of assays. All of the subject compounds demonstrated a lower order of dopamine-like activity than the tetralin derivatives. Some of the subject compounds showed weak interactions with al-and ...