Induction of apoptosis promoted by Bang52; a small molecule that downregulates Bcl-x L

M Rossi, J Bang, S Mazur, JA Iera, DC Phillips…

Index: Rossi, Matteo; Bang, Jeong-kyu; Mazur, Sharlyn; Iera, Jaclyn A.; Phillips, Darren C.; Zambetti, Gerard P.; Appella, Daniel H. Bioorganic and Medicinal Chemistry Letters, 2009 , vol. 19, # 9 p. 2429 - 2434

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Abstract

Cancer cells evade death by over-producing specific proteins that inhibit apoptosis. One such group of proteins is the Bcl-2 family, of which Bcl-xL is an important member. This protein binds and inhibits BAK, another protein that promotes apoptosis. While the development of chemical inhibitors that block Bcl-xL–BAK association have been the focus of intense research efforts, we demonstrate in this manuscript an alternative strategy to ...