Inhibition of Src kinase activity by 7-[(2, 4-dichloro-5-methoxyphenyl) amino]-2-heteroaryl-thieno [3, 2-b] pyridine-6-carbonitriles

…, ACB Sosa, JJ Chen, JM Golas, F Boschelli

Index: Boschelli, Diane H.; Wu, Biqi; Barrios Sosa, Ana Carolina; Chen, Joan J.; Golas, Jennifer M.; Boschelli, Frank Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 21 p. 4681 - 4684

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Citation Number: 21

Abstract

7-[(2, 4-Dichloro-5-methoxyphenyl) amino] thieno [3, 2-b] pyridine-6-carbonitriles with various heteroaryl groups at C-2 are inhibitors of Src kinase activity. Of these new analogs, compounds substituted at C-2 by a 3, 5-furan or a 2, 5-pyridine had the best activity in the Src enzyme and cell assays.