Efficient Protein Encapsulation within Thermoresponsive Coacervate-Forming Biodegradable Polyesters

Megan A. Cruz, Daniel L. Morris, John P. Swanson, Mangaldeep Kundu, Steven G. Mankoci, Thomas C. Leeper, Abraham Joy

Index: 10.1021/acsmacrolett.8b00118

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Abstract

Presented here is a novel method for encapsulating proteins into biodegradable, thermoresponsive coacervate-type polyesters. Bovine serum albumin (BSA) was efficiently incorporated into coacervate droplets via a simple thermoresponsive encapsulation mechanism. Tunable modular systems for encapsulation such as the one presented here may be useful in a range of protein delivery applications.