Labeled 3-aryl-4-indolylmaleimide derivatives and their potential as angiogenic PET biomarkers

O Ilovich, H Billauer, S Dotan, E Mishani

Index: Ilovich, Ohad; Billauer, Hana; Dotan, Sharon; Mishani, Eyal Bioorganic and Medicinal Chemistry, 2010 , vol. 18, # 2 p. 612 - 620

Full Text: HTML

Citation Number: 10

Abstract

In a continued effort to find a suitable PET tracer for visualization of angiogenic processes, we explored the 3, 4-diarylmaleimide family, known to have high affinity and selectivity towards the VEGFR-TKs. One previously reported agent and three new halogen-containing 3, 4-diarylmaleimide derivatives were synthesized. The four maleimide derivatives were evaluated for their affinity and selectivity towards the VEGFRs and exhibited promising ...