New myocardial imaging agents: stabilization of radioiodine as a terminal vinyl iodide moiety on tellurium fatty acids

FF Knapp Jr, MM Goodman, AP Callahan…

Index: Knapp, F. F.; Goodman, M. M.; Callahan, A. P.; Ferren, L. A.; Kabalka, G. W.; Sastry, K. A. R. Journal of Medicinal Chemistry, 1983 , vol. 26, # 9 p. 1293 - 1300

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Citation Number: 31

Abstract

To determine the myocardial uptake and retention properties of radioiodinated tellurium fatty acids, we prepared two new tellurium fatty acids in which iodine-126 has been chemically stabilized by attachment as a trans-vinyl iodide (I-CH= CH-Et-TeR'4OOH) and evaluated them in rats. Fabrication of 18-iodo-13-te11ura-17-octadecenoic acid was accomplished by coupling 1, 5-diiodo-l-pentene with sodium 12-(methoxycarbonyl)-n-dodecan-l-yl telluride. ...