Efficient synthesis of anacardic acid analogues and their antibacterial activities
…, JX Huang, AAB Robertson, MA Cooper
Index: Mamidyala, Sreeman K.; Ramu, Soumya; Huang, Johnny X.; Robertson, Avril A.B.; Cooper, Matthew A. Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 6 p. 1667 - 1670
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Citation Number: 3
Abstract
Anacardic acid derivatives exhibit a broad range of biological activities. In this report, an efficient method for the synthesis of anacardic acid derivatives was explored, and a small set of salicylic acid variants synthesised retaining a constant hydrophobic element (a naphthyl tail). The naphthyl side chain was introduced via Wittig reaction and the aldehyde installed using directed ortho-metalation reaction of the substituted o-anisic acids. The failure of ...
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