One-pot copper (I)-catalyzed synthesis of 3, 5-disubstituted isoxazoles
TV Hansen, P Wu, VV Fokin
Index: Hansen, Trond V.; Wu, Peng; Fokin, Valery V. Journal of Organic Chemistry, 2005 , vol. 70, # 19 p. 7761 - 7764
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Citation Number: 170
Abstract
3, 5-Disubstituted isoxazoles are obtained in good yields by a convenient one-pot, three- step procedure utilizing a regioselective copper (I)-catalyzed cycloaddition reaction between in situ generated nitrile oxides and terminal acetylenes. Most functional groups do not interfere with the reaction, which can be performed in aqueous solvents without protection from oxygen. Since all reagents are used in stoichiometric amounts, formation of ...
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