Thiadiazole derivatives as potential anticonvulsant agents

P Mullick, SA Khan, S Verma…

Index: Mullick, Pooja; Khan, Suroor A.; Verma, Surajpal; Alam, Ozair Bulletin of the Korean Chemical Society, 2011 , vol. 32, # 3 p. 1011 - 1016

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Citation Number: 17

Abstract

Abstract A series of thiadiazole derivatives were synthesized with differently substituted benzoic acids which were cyclized to give differently substituted thiazolidin-4-one. Elemental analysis, IR, NMR, NMR and mass spectral data confirmed the structure of the synthesized compounds. The derivatives of these moieties were evaluated for anticonvulsant activity by MES model and neurotoxicity by rotarod method. The synthesized compounds showed ...