A facile synthesis of emodin derivatives, emodin carbaldehyde, citreorosein, and their 10-deoxygenated derivatives and their inhibitory activities on μ-calpain

…, JK Son, HW Chang, JE Eom, Y Kwon, Y Jahng

Index: Liang, Jing Lu; Cha, Hyo Chang; Lee, Seung Ho; Son, Jong-Keun; Chang, Hyeun Wook; Eom, Ji-Eun; Kwon, Youngjoo; Jahng, Yurngdong Archives of Pharmacal Research, 2012 , vol. 35, # 3 p. 447 - 454

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Citation Number: 5

Abstract

Abstract A new procedure for the preparation of emodin carbaldehyde and citreorosein was described, in which, ω, ω′-dibromomethylemodin triacetate was prepared as a key intermediate by NBSmediated bromination of 1, 3, 8-triacetylemodin. Reduction of emodin and citreorosein with SnCl 2 in a 1: 1 mixture of HOAc and HCl afforded the corresponding anthrones in 90% and 92% yield, respectively, while the corresponding 10-desoxyemodin ...