Journal of the American Chemical Society

The Preparation of Substituted 4-Aminomethylpiperidines and their Straight Chain Analogs1

CE Kwartler, P Lucas

Index: Kwartler; Lucas Journal of the American Chemical Society, 1947 , vol. 69, p. 2582,2585

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Citation Number: 3

Abstract

Summary 1. Acid chlorides react readily in the presence of zinc chloride to cleave the tetrahydropyran ring, forming 5-chloroamyl esters. 2. 5-Diethylaminopentanol-1 has been prepared in 44.5% over-all yield in three steps starting with benzoyl chloride and tetrahydropyran in the presence of zinc chloride, followed by replacement of the chlorine atom by a diethylamino group and hydrolysis.