Cobalt??Catalyzed Oxidative Isocyanide Insertion to Amine??Based Bisnucleophiles: Diverse Synthesis of Substituted 2??Aminobenzimidazoles, 2??Aminobenzothiazoles …
TH Zhu, SY Wang, GN Wang…
Index: Zhu, Tong-Hao; Wang, Shun-Yi; Wang, Gao-Nan; Ji, Shun-Jun Chemistry - A European Journal, 2013 , vol. 19, # 19 p. 5850 - 5853
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Citation Number: 36
Abstract
2-Aminobenzoxazoles, 2-aminobenzothiazoles, and 2-aminobenzimidazoles are privileged heteroaromatic scaffolds in biologically active compounds and natural products (Figure 1). For example, the core scaffold of the selective inhibitor of the human P2Y1 receptor I [1] and the drug for treating insomnia II [2] is 2-aminobenzoxazole. The core structure of the anti-HIV agent III [3] and the phosphodiesterase 10 inhibitor IV [4] is 2-aminobenzothiazole. The ...
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