Synthesis and evaluation of curcumin-related compounds for anticancer activity

…, ZY Du, X Zheng, XX Cui, AH Conney, K Zhang

Index: Wei, Xingchuan; Du, Zhi-Yun; Zheng, Xi; Cui, Xiao-Xing; Conney, Allan H.; Zhang, Kun European Journal of Medicinal Chemistry, 2012 , vol. 53, p. 235 - 245

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Citation Number: 46

Abstract

Sixty-one curcumin-related compounds were synthesized and evaluated for their anticancer activity toward cultured prostate cancer PC-3 cells, pancreas cancer Panc-1 cells and colon cancer HT-29 cells. Inhibitory effects of these compounds on the growth of PC-3, Panc-1 and HT-29 cells were determined by the MTT assay. Compounds E10, F10, FN1 and FN2 exhibited exceptionally potent inhibitory effects on the growth of cultured PC-3, Panc-1 ...