A Convenient Synthesis of 5-and 6-Substituted 2-Phenyl-3H-pyrimidin-4-ones

N Zanatta, L Fantinel, RV Lourega, HG Bonacorso…

Index: Zanatta, Nilo; Fantinel, Leonardo; Lourega, Rogerio V.; Bonacorso, Helio G.; Martins, Marcos A. P. Synthesis, 2008 , # 3 p. 358 - 362

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Citation Number: 10

Abstract

Scheme [1] outlines the synthesis of a series of 5- or 6-substituted 2-phenyl-3H-pyrimidin-4-ones from the reactions of the enones 1a-o with benzamidine hydrochloride. In order to obtain better yields, three methods were tested (Scheme [1] ). Table [1] presents the optimized results obtained after each reaction was carried out by the three methods. It is important to mention that method A was the method of choice for most reactions, because it furnished better yields and ...