Tetrahedron letters
Solid-phase synthesis of unsymmetrical ureas through the use of Kenner safety-catch linker
D Fattori, P D'Andrea, M Porcelloni
Index: Fattori, Daniela; D'Andrea, Piero; Porcelloni, Marina Tetrahedron Letters, 2003 , vol. 44, # 4 p. 811 - 814
Full Text: HTML
Citation Number: 12
Abstract
A new strategy for the solid-phase synthesis of unsymmetrical ureas is described. Upon treatment of Kenner safety-catch linker with an isocyanate, followed by TMSCHN2 or iodoacetonitrile and an amine, the corresponding unsymmetrical ureas are released in solution.
Related Articles:
Efficient synthesis of polysubstituted acylguanidines and guanylureas
[Katritzky, Alan R.; Rogovoy, Boris V.; Cai, Xiaohong; Kirichenko, Nataliya; Kovalenko, Katherine V. Journal of Organic Chemistry, 2004 , vol. 69, # 2 p. 309 - 313]