Tetrahedron Letters

Concise total synthesis of 9-methoxystrobilurin A

H Uchiro, K Nagasawa, Y Aiba, S Kobayashi

Index: Uchiro, Hiromi; Nagasawa, Koh; Aiba, Yasuyuki; Kobayashi, Susumu Tetrahedron Letters, 2000 , vol. 41, # 21 p. 4165 - 4168

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Citation Number: 17

Abstract

9-Methoxystrobilurin A (1) was isolated by Anke and Steglich et al. in 1995 1 as a new and potent analogue of antifungal β-methoxyacrylates. 2 Structurally complicated strobilurin K (2) 1. and 3. and L (3) 6 were also isolated in 1996, and they have a unique triene moiety including two electron-rich and acid-sensitive methyl enol ethers as common substructures. Interestingly, this 9-methoxystrobilurin family was found to exhibit potent cytostatic activity toward human- ...