Tetrahedron

Total synthesis of a dienynone from Echinacea pallida

S Morandi, F Pellati, S Benvenuti, F Prati

Index: Morandi, Stefania; Pellati, Federica; Benvenuti, Stefania; Prati, Fabio Tetrahedron, 2008 , vol. 64, # 27 p. 6324 - 6328

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Citation Number: 17

Abstract

The first total synthesis of (8Z, 13Z)-pentadeca-8, 13-dien-11-yn-2-one is described. This dienynone was recently isolated from the n-hexane extract of Echinacea pallida roots and displayed a selective cytotoxic activity toward cancer cells, thus featuring as a potential anticancer lead. The product was obtained in 11 steps in 25% overall yield.