Novel synthetic analogs of the Pseudomonas autoinducer

…, BH Iglewski, T De Kievit, Y Kakai, L Passador

Index: Kline; Bowman; Iglewski; De Kievit; Kakai; Passador Bioorganic and Medicinal Chemistry Letters, 1999 , vol. 9, # 24 p. 3447 - 3452

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Citation Number: 88

Abstract

Release of virulence factors in Pseudomonas aeruginosa is regulated by two N- acylhomoserine lactones, PAI-1 and PAI-2, that activate the respective transcription factors LasR and RhlR. With the goal of developing novel therapeutic agents, we synthesized constrained analogs of PAI-1 and evaluated them in P. aeruginosa. Two of the novel analogs bound to LasR and showed agonist activity in LasR stimulation of a lasI-lacZ ...