A new efficient total synthesis of vindorosine and vindoline

RZ Andriamialisoa, N Langlois…

Index: Andriamialisoa, Ratremaniaina Zo; Langlois, Nicole; Langlois, Yves Journal of Organic Chemistry, 1985 , vol. 50, # 7 p. 961 - 967

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Citation Number: 59

Abstract

route affording anhydrovinblastine (4), and vinblastine (3) from vindoline (lb) and catharanthine Nb-oxide (2b), by a fragmentation induced by the modified Polonovski reaction,'increased the interest in the total syntheses of these alkaloids. We wish to disclose in the present paper a new efficient synthesis leading to vindorosine (11- desmethoxyvindoline)(la) and vindoline (lb) by a route following a" retrobiomimetic" ...

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