Copper (II)–acid co-catalyzed intermolecular substitution of electron-rich aromatics with diazoesters

E Tayama, M Ishikawa, H Iwamoto, E Hasegawa

Index: Tayama, Eiji; Ishikawa, Moe; Iwamoto, Hajime; Hasegawa, Eietsu Tetrahedron Letters, 2012 , vol. 53, # 38 p. 5159 - 5161

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Citation Number: 11

Abstract

The intermolecular aromatic substitution of N, N-dialkylanilines and alkoxybenzenes with diazoesters is shown to proceed in the presence of catalytic amounts of both copper (II) salt and acid (Lewis or Brønsted). This method is a mild and rare metal-free C–C bond formation reaction between aromatic (sp2) and aliphatic (sp3) carbons.