Antimicrobial activity of nitro derivatives of azolo [1, 5-a]-pyrimidine and azolo [5, 1-c][1, 2, 4] triazine

…, ON Chupakhin, EA Kiprianova, AD Garagulya

Index: Rusinov, V. L.; Myasnikov, A. V.; Pilicheva, T. L.; Chupakhin, O. N.; Kiprianova, E. A.; Garagulya, A. D. Pharmaceutical Chemistry Journal, 1990 , vol. 24, # 1 p. 52 - 54 Khimiko-Farmatsevticheskii Zhurnal, 1990 , vol. 24, # 1 p. 39 - 40

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Citation Number: 14

Abstract

To search for effective antimicrobial preparations and also to study the relationship between their structure (nature and position of the substituents at the azole and azine parts of the molecule) and the biological activity we have carried out the synthesis of a series of nitro derivatives of azolo [1, 5-a]-pyrimidine (I, III, IV, V) and also of their aza analogs, azolo [5, lc][1, 2, 4] triazines (II, VI-X)(see reaction scheme). 6-Nitro-l, 2, 4-triazolo [l, 5-a] ...