Folate analogs. 24. Syntheses of the antitumor agents 10-deazaaminopterin (10-DAAM) and 10-ethyl-10-deazaaminopterin (10-EDAAM)

MG Nair

Index: Nair, M. G. Journal of Organic Chemistry, 1985 , vol. 50, # 11 p. 1879 - 1884

Full Text: HTML

Citation Number: 12

Abstract

Methods have been developed for the chemical synthesis of two recently described potent antitumor agents. They are 10-deazaaminopterin (10-DUM)(2) and 10-ethyl-10- deazaaminopterin(10-EDAAM)(3). The methods described in this paper have general applicability for the synthesis of a variety of hitherto difficultly accessible 10-substituted-10- dedolic acids and analogues. Reaction of methyl p-formylbenzoate (7) with the Wittig ...