Journal of medicinal chemistry

Catechol O-methyltransferase. 11. Inactivation by 5-hydroxy-3-mercapto-4-methoxybenzoic acid

RT Borchardt, JH Huber

Index: Borchardt, Ronald T.; Huber, Joan A. Journal of Medicinal Chemistry, 1982 , vol. 25, # 3 p. 321 - 323

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Citation Number: 5

Abstract

Results Synthesis. The synthesis (Scheme I) of 5-hydroxy-3-mercapto-4-methoxybenzoic acid (5) was initiated from the 3-nitro analogue of isovanillic acid (l), which was readily available.* The reduction of the nitro compound 1 to the corresponding amine 2 was accomplished using catalytic hydrogenation conditions. Compound 2 was diazotized