Structural Features Important for. sigma. 1 Receptor Binding

…, AM Ismaiel, MB El-Ashmawy, JB Fischer…

Index: Glennon; Ablordeppey; Ismaiel; El-Ashmawy; Fischer; Howie Journal of Medicinal Chemistry, 1994 , vol. 37, # 8 p. 1214 - 1219

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Citation Number: 112

Abstract

Two problems that have hampered u receptor research are (i) a lack of high-affinity agents and (ii) the recent identification of multiple populations of u receptors (ie, u1 and 6 2 sites). Recently, several high-affinity u ligands have been identified, and the term superpotent u ligands has been coined to describe agents with Ki values of< 1 nM. We have previously shown that appropriately N-substituted phenylalkylamines bind at u receptors with high ...

The facile preparation of primary and secondary amines via an improved Fukuyama–Mitsunobu procedure. Application to the synthesis of a lung-targeted gene …

[Guisado, Cristina; Waterhouse, Jodie E.; Price, Wayne S.; Jorgensen, Michael R.; Miller, Andrew D. Organic and Biomolecular Chemistry, 2005 , vol. 3, # 6 p. 1049 - 1057]

Secondary Products from the Catalytic Hydrogenation of Nitriles1, 2

[Juday; Adkins Journal of the American Chemical Society, 1955 , vol. 77, p. 4559,4563]

Enamidines. Versatile vehicles for homologation of carbonyl compounds

[Meyers, A. I.; Jagdmann, G. Erik Journal of the American Chemical Society, 1982 , vol. 104, # 3 p. 877 - 879]