Journal of medicinal chemistry

Antiparasitic 5-nitrothiazoles and 5-nitro-4-thiazolines. 3

PJ Islip, MD Closier, MC Neville

Index: Islip,P.J. et al. Journal of Medicinal Chemistry, 1973 , vol. 16, p. 1030 - 1034

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Citation Number: 7

Abstract

(11). Method B. Isovaleryl chloride (10.88 g, 20% excess) was added dropwise to a solution of nitrile 1 (14.85 g) in pyridine (75 ml) at 10". The mixture was stirred at room temperature (time given) and then poured into H, O. The aqueous layer was decanted from the oil, which was then washed with H, O and triturated with i-PrOH. Several crops of material were obtained, and these were combined and recrystallized (twice) from i-PrOH (charcoal) to ...