A non-toxic Hsp90 inhibitor protects neurons from Aβ-induced toxicity

…, L Neckers, KL Audus, ML Michaelis, BSJ Blagg

Index: Ansar, Sabah; Burlison, Joseph A.; Hadden, M. Kyle; Yu, Xiao Ming; Desino, Kelly E.; Bean, Jennifer; Neckers, Len; Audus, Ken L.; Michaelis, Mary L.; Blagg, Brian S.J. Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 7 p. 1984 - 1990

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Citation Number: 92

Abstract

The molecular chaperones have been implicated in numerous neurodegenerative disorders in which the defining pathology is misfolded proteins and the accumulation of protein aggregates. In Alzheimer's disease, hyperphosphorylation of tau protein results in its dissociation from microtubules and the formation of pathogenic aggregates. An inverse relationship was demonstrated between Hsp90/Hsp70 levels and aggregated tau, ...