Synthesis of antibiotic stilbenes using organomanganese arene complexes

…, WH Miles, PM Smiley, WS Lester…

Index: Krow, Grant R.; Miles, William H.; Smiley, Patricia M.; Lester, Walden S.; Kim, Yong J. Journal of Organic Chemistry, 1992 , vol. 57, # 14 p. 4040 - 4043

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Citation Number: 19

Abstract

The two antibiotic metabolites isolated from strain Hb of Xenorhabdus, a genus of bacteria symbionts which live in the guts of parasitic nemat~ des,'-~ have been identified as the homologous trans-hydroxystilbene derivatives la and lb. 2* 3 In order to conduct further biological testing of antibiotics la and lb, 4 we sought an expedient synthesis based on the readily available 1, 3-dimethoxy-2-alkylbenzenes. We envisioned that the direct ...