Sterically hindered chelating alkyl phosphines provide large rate accelerations in palladium-catalyzed amination of aryl iodides, bromides, and chlorides, and the first …

BC Hamann, JF Hartwig

Index: Hamann; Hartwig Journal of the American Chemical Society, 1998 , vol. 120, # 29 p. 7369 - 7370

Full Text: HTML

Citation Number: 375

Abstract

Aromatic phosphines and arsines are typically used as ligands in synthetically valuable palladium-catalyzed cross-coupling processes that include recently developed couplings to form arylamines and aryl ethers from aryl halides and triflates. 1-3 We have recently sought palladium systems comprised of air stable components that provide faster reaction rates for aryl bromide and iodide amination and allow the amination of less activated and ...