Semisynthetic Macrolide Antibacterials Derived from Tylosin. Synthesis and Structure-Activity Relationships of Novel Desmycosin Analogues 1

S Mutak, N Maršic, MD Kramaric…

Index: Mallams, Alan K.; Rossman, Randall R. Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1989 , p. 799 - 805

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Citation Number: 16

Abstract

... Journal of Medicinal ... With the rest of the functionality suitably protected, we were now ready to chemically manipulate the aglycon C-3 alcohol. ... Comparison of the chemical shift of the ketone carbonyl at the 9-position in 22, 24a, and 24b revealed a downfield shift of 3.8 ppm in ...