Divergent total synthesis of the natural antimalarial marinoquinolines A, B, C, E and unnatural analogues

CS Schwalm, CRD Correia

Index: Schwalm, Cristiane Storck; Correia, Carlos Roque D. Tetrahedron Letters, 2012 , vol. 53, # 36 p. 4836 - 4840

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Citation Number: 21

Abstract

A new synthetic route to marinoquinolines was developed, allowing the synthesis of several structurally related compounds from a common key intermediate. Four natural marinoquinolines (A, B, C and E) and nine unnatural new analogues were prepared by this strategy, which features a Heck–Matsuda reaction in pure water and the Pictet–Spengler reaction as key steps.