Synthesis and anti-herpes simplex activity of analogs of phosphonoacetic acid

TR Herrin, JS Fairgrieve, RR Bower…

Index: Herrin; Fairgrieve; Bower; et al. Journal of Medicinal Chemistry, 1977 , vol. 20, # 5 p. 660 - 663

Full Text: HTML

Citation Number: 34

Abstract

The synthesis of monoesters (P and C) of phosphonoacetic acid (PA) is given. The carboxyl esters were prepared by two methods: the reaction of chloroacetates with tris (trimethylsily1) phosphite, followed by hydrolysis; and by the acid-catalyzed esterification of PA with the appropriate alcohol. P-Monoesters of PA were prepared either by the reaction of alkyl [bis (trimethylsilyl)] phosphite with benzyl chloroacetate followed by deprotection or by the ...