A synthesis of 2-and 4 (5)-(2-pyridinyl) imidazoles by palladium-catalysed cross-coupling reactions
AS Bell, DA Roberts, KS Ruddock
Index: Bell, A. S.; Roberts, D. A.; Ruddock, K. S. Tetrahedron Letters, 1988 , vol. 29, # 39 p. 5013 - 5016
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Citation Number: 54
Abstract
Abstract N-Substituted imidazolylzinc chlorides were reacted with 2-bromopyridine in the presence of Pd (PPh 3) 4 and a two-fold excess of ZnCl 2 to afford cross-coupled products in 58–93% yields. Deprotection provided convenient routes to 2-or 4 (5)-(2-pyridinyl) imidazoles.
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