Heterocycles

A convenient procedure for the synthesis of substituted 4-methylaminocoumarins

KHA Al-Zghoul, KSM Salih, MT Ayoub…

Index: Al-Zghoul, Khadeejh H.; Salih, Kifah S.M.; Ayoub, Mikdad T.; Mubarak, Mohammad S. Heterocycles, 2005 , vol. 65, # 12 p. 2937 - 2947

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Citation Number: 22

Abstract

Abstract-3-Bromo-7-methoxy-4-methylcoumarin and 3-bromo-4, 7-dimethylcoumarin give a mixture of the corresponding 3-aminocoumarins and 4-aminomethylcoumarins upon the reaction with a number of secondary amines. In addition, the reaction of 7-methoxy-and 7- methyl-4-bromomethylcoumarins with secondary diamines affords the corresponding N, N- dicoumarinmethyldiamine.