Reassessment of nanomaterials immunotoxicity

Mahmoud Elsabahy, Karen L. Wooley

Index: 10.1016/j.nantod.2018.01.002

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Abstract

Biomarkers (e.g. cytokines) that are commonly measured to assess the immunomodulatory effects of nano- or micro-particulates may be adsorbed on their surfaces and/or absorbed within internal regions, thereby, generating an inaccurately low measure of immunotoxic effect. We provide this commentary, therefore, as a cautionary recommendation that previously published data be reassessed, and future investigations consider potential artifacts and data misinterpretation carefully.