Inorganic chemistry

Thioester Hydrolysis Promoted by a Mononuclear Zinc Complex

JJ Danford, AM Arif, LM Berreau

Index: Danford, James J.; Arif, Atta M.; Berreau, Lisa M. Inorganic Chemistry, 2010 , vol. 49, # 3 p. 778 - 780

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Abstract

The mononuclear zinc complex [(bpta) Zn](ClO4) 2· 0.5 H2O (1) promotes the hydrolysis of the thioester PhCH (OH) C (O) SCD3 in CH3CN: H2O (50: 50; buffered at pH 9.0). This reaction gives mandelate, CD3SH, and a zinc thiolate complex as products, with the ratio of the sulfur-containing species depending on the metal complex concentration. Kinetic studies (via 2H NMR) indicate a rate-determining step that is second order overall. The activation ...