Decarboxylation of peptide-bound aminomalonic acid

P Wheelan, WM Kirsch, TH Koch

Index: Wheelan, Pat; Kirsch, Wolff M.; Koch, Tad H. Journal of Organic Chemistry, 1989 , vol. 54, # 6 p. 1364 - 1370

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Citation Number: 9

Abstract

The kinetics of decarboxylation of the monopeptide of aminomalonic acid (Ama), Na-acetyl- Ama N-ethylamide, to the corresponding monopeptide of glycine (Gly), Na-acetyl-Gly N- ethylamide, are described. The rate constants for decarboxylation of the anionic and neutral species at 120 OC in aqueous medium are 0.002 22 and 0.26 min-', respectively, and the pK, relating these species is 2.33. The Arrhenius activation energy and preexponential ...