Synthesis of some ureidodihydrofurans and related pyrimidones as potential antimalarials

E Campaigne, RL Ellis, M Bradford…

Index: Campaigne,E. et al. Journal of Medicinal Chemistry, 1969 , vol. 12, # 2 p. 339 - 342

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Citation Number: 39

Abstract

Discussion Sirice it his been reported that cr-cS. Llrio-y-lactoiie~ arc c. apable of coridensatiori with guanidine, urea, or i hiourca" arid: ire susecptible to re: irrangemeiit employing: I sodium allioxide salt lo or roncentr: itcd SH, OH to yield 2-amino-~- carboallioxydihydrofurnlii and"-nmirio-:~-carboxamidodihydrofuraIi~, respectively,: lttcnipts werc directed toward the preparatioii of ac, y: iriobutyrolactoiies of type 3. Reaction of 2a ...