Steroids

Novel steroidal pure antiestrogens

J Bowler, TJ Lilley, JD Pittam, AE Wakeling

Index: Bowler; Lilley; Pittam; Wakeling Steroids, 1989 , vol. 54, # 1 p. 71 - 99

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Citation Number: 216

Abstract

Abstract A series of steroidal estrogen antagonists with no intrinsic estrogenicity in rat uterotrophic-antiuterotrophic tests has been discovered. The compounds are derivatives of estradiol containing amidoalkyl side chains at the 7α-position. The most potent compounds are Nn-butyl-N-methyl-11-(3, 17β-dihydroxyestra-1, 3, 5 (10)-trien-7α-yl) undecanamide and N-2, 2, 3, 3, 4, 4, 4-heptafluorobutyl-N-methyl-11-(3, 17β-dihydroxyestra-1, 3, 5 (10)-trien- ...