Solution-phase combinatorial synthesis and evaluation of piperazine-2, 5-dione derivatives

WA Loughlin, RL Marshall, A Carreiro…

Index: Loughlin, Wendy A.; Marshall, Raymond L.; Carreiro, Adelina; Elson, Kathryn E. Bioorganic and Medicinal Chemistry Letters, 2000 , vol. 10, # 2 p. 91 - 94

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Citation Number: 29

Abstract

Combinatorial chemistry 1, 2 and 3 is providing a new and improved approach to the discovery of new and better pharmacological agents. Small molecule libraries have been rapidly accessed using a variety of methodologies and techniques that have been developed for use in solid-phase 4 and 5 as well as solution-phase synthesis. 6 Although solid-phase synthesis has been at the forefront of combinatorial chemistry, parallel solution-phase synthesis is an interesting ...