Design, synthesis and biological evaluation of new aryl thiosemicarbazone as antichagasic candidates
L Blau, RF Menegon, GHG Trossini, JVD Molino…
Index: Blau, Lorena; Menegon, Renato Farina; Trossini, Gustavo H. G.; Molino, Joao Vitor Dutra; Vital, Drielli Gomes; Cicarelli, Regina Maria Barretto; Passerini, Gabriela Duo; Bosquesi, Priscila Longhin; Chin, Chung Man European Journal of Medicinal Chemistry, 2013 , vol. 67, p. 142 - 151
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Citation Number: 16
Abstract
Abstract The present work reports on the synthesis, biological assaying and docking studies of a series of 12 aryl thiosemicarbazones, which were planned to act over two main enzymes, cruzain and trypanothione reductase. These enzymes are used as targets of trypanocidal activity in Chagas disease control with a minimal mutagenic profile. Three p- nitroaromatic thiosemicarbazones showed high activity against Trypanosoma cruzi in in ...
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