Synthesis of fluorinated pyridines by the balz??schiemann reaction. An alternative route to enoxacin, a new antibacterial pyridonecarboxylic acid

JI Matsumoto, T Miyamoto, A Minamida…

Index: Matsumoto; Miyamoto; Minamida; et al. Journal of Heterocyclic Chemistry, 1984 , vol. 21, # 3 p. 673 - 679

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Citation Number: 47

Abstract

Abstract Fluorination of the 2, 6-disubstituted 3-aminopyridines 5 and 12 by the Balz- Schiemann reaction is described. 2, 6-Dichloro-3-pyridinediazonium tetrafluoroborate (6) and 2-substituted 6-acetylamino-3-pyridinediazonium tetrafluoroborates 13 were heated with or without a solvent to give the corresponding fluorinated pyridines 7 and 14, respectively, in good yields. 2-Substituted 6-acetylamino-3-fluoropyridines (14) were ...