A Novel Synthesis of fluorinated pyrazoles via Gold (I)-catalyzed tandem aminofluorination of alkynes in the presence of selectfluor

J Qian, Y Liu, J Zhu, B Jiang, Z Xu

Index: Qian, Jianqiang; Liu, Yunkui; Zhu, Jie; Jiang, Bo; Xu, Zhenyuan Organic Letters, 2011 , vol. 13, # 16 p. 4220 - 4223

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Citation Number: 79

Abstract

Pyrazoles constitute an important class of N-heterocycles, exhibiting unique pharmaceutical and biological activities.(1) Recently, the fluorine-containing pyrazoles have received special attention due to their interesting biological properties serving as precursors for pharmaceuticals and pesticides.(2) However, the number of published routes to these compounds is fairly limited mainly due to the difficulty of introducing a fluorine atom into heterocycles.(2, 3) The ...