Tetrahedron

Total synthesis of cyclostellettamine C, a bispyridinium macrocyclic alkaloid having muscarinic acetylcholine receptor antagonistic activity

…, N Seki, O Noshiro, K Honda, K Yasumuro, T Ozasa…

Index: Anan, Hideki; Seki, Norio; Noshiro, Osamu; Honda, Kazuo; Yasumuro, Kenichi; Ozasa, Teruaki; Fusetani, Nobuhiro Tetrahedron, 1996 , vol. 52, # 33 p. 10849 - 10860

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Citation Number: 29

Abstract

Cyclostellettamine C (1), a bispyridinium macrocyclic compound having muscarinic acetylcholine receptor antagonistic activity, was synthesized by the stepwise ring closure method via 3-(13-hydroxytridecyl)-1-[13-(3-pyridyl) tridecyl] pyridinium trifluoromethanesulfonate (21). Through this study, the structure of naturally originating 1 was synthetically and biologically confirmed.

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