Convenient Synthesis of Nucleoside??5′??Diphosphates from the Corresponding Ribonucleoside??5′??phosphoroimidazole

AR Kore, G Parmar

Index: Kore, Anilkumar R.; Parmar, Gaurang Synthetic Communications, 2006 , vol. 36, # 22 p. 3393 - 3399

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Citation Number: 12

Abstract

Abstract The reaction of ribonucleoside??5′??phosphoroimidazolide with a tributylammonium orthophosphate in anhydrous dimethylformamide at room temperature provides a general method for the synthesis of nucleoside??5′??diphosphates. The novelty of the approach is to use the triethylammonium salt of 5′??monophosphate nucleoside derivative prior to the imidazolate reaction with imidazole, triphenylphosphine, and 2, 2′??dithiodipyridine. ...