Advanced Synthesis & Catalysis

Rhodium (III)??Catalyzed Oxidative Olefination of Picolinamides: Convenient Synthesis of 3??Alkenylpicolinamides

J Zhou, B Li, ZC Qian, BF Shi

Index: Zhou, Jun; Li, Bo; Qian, Zhen-Chao; Shi, Bing-Feng Advanced Synthesis and Catalysis, 2014 , vol. 356, # 5 p. 1038 - 1046

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Citation Number: 16

Abstract

Abstract: A rhodiumACHTUNGTRENNUNG (III)-catalyzed selective olefination of picolinamide derivatives has been developed. The reaction shows high regioselectivity, low catalyst loading (0.5 mol%), high yield and good functional group tolerance, providing a convenient strategy for the synthesis of 3-alkenylpicolinamides. Keywords: CÀH activation; oxidative olefination; pyridines; rhodium